盐酸头孢吡肟与精氨酸共沉淀行为研究Study on Coprecipitation of Cefepime hydrochloride and Arginine
马金菊,王振强,刘伟
摘要(Abstract)：
通过改变盐酸头孢吡肟和L-精氨酸的摩尔比,采用共沉淀的方法制备出了一系列组合物,利用高效液相色谱(HPLC)、红外光谱(IR)和X射线粉末衍射(XRPD)等技术对产品的组成及结晶情况进行了研究,结果显示:在采用共沉淀方法制备的组合物中,盐酸头孢吡肟和精氨酸的摩尔比与投料的摩尔比基本相同,即得到的共沉淀产品为固体溶液,而不是共晶。均一度测试表明,以各种投料比制备的产品均匀性均优于市售物理混合产品。
关键词(KeyWords)： 盐酸头孢吡肟;精氨酸;共沉淀;溶剂体系
基金项目(Foundation):
作者(Author): 马金菊,王振强,刘伟
DOI: 10.13681/j.cnki.cn41-1282/tv.2017.03.013
参考文献(References)：
- [1]弋东旭,洪鸣凰,徐军,等.药物共晶研究进展及应用[J].中国抗生素杂志,2011,36(8):561-565.
- [2]易涵,尹亚妹,赵秀丽,等.伊曲康唑共晶的制备与表征[J].沈阳药科大学学报,2014(3):161-168.
- [3]王义成,冯成亮,杨素勤,等.药物共晶的最新研究进展[J].药学进展,2013,37(3):120-130.
- [4]Stahly G P.Diversity in single-and multiple-component crystals.The search for and prevalence of polymorphs and cocrystals[J].Cryst Growth Des,2007,7(6):1007-1026.
- [5]Son S F,A say B,Busse J R,et al.Reaction propagation of Al/Mo O3 nanocomposite thermites[A].Proceedings of the International Pyrotechnics Seminar[C].28th.2001,833-843.
- [6]杨永明,张建国.LAN系共沉淀起爆药的制备工艺与性能研究[J].含能材料,2001,9(3):107-110.
- [7]Aisawa S,Takahashi S,Ogasawara WYNarita E.Direct intercalation of amino acids into layered double hydroxides by coprecipitation[J].Solid State Chem.,2001,162(1):52-62.
- [8]Bristol-Myers Company.Cefepime cephalosporin salts:U.S.Patent,4,910,301[P].1990-03-20.
- [9]Bristol-Myers Company.Cephalosporin salts and injectable compositions,U.S.Patent,4,994,451[P].1991-02-19.
- [10]Bristol-Myers Squibb Company.Injectable compositions of cefepime dihydrochloride hydrate:U.S.Patent,5,244,891[P].1993-09-14.
- [11]Bristol-Myers Company.Lyophilized or precipitated cephalosporin zwitterion and salt combination:U.S.Patent,4,808,617[P].1989-02-28.
- [12]Lupin Ltd(IN),Tyagi OM Dutt(IN),Chauhan Yogendra Kumar(IN),Srivastava Tushar Kumar(IN).A co-precipitated cefepime composition and process for preparation thereof.WO2005IN00095[P].2005-10-13.